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The following individual and combined search terms were used: GLP-1, Semaglutide and Liraglutide, molecular mechanism, lipid metabolism, insulin metabolism, glucose homeostasis, energy expenditure obesity treatment, type 2 diabetes mellitus, side effects, clinical trials, treatment option, fatty liver disease, hypertension, neurodegenerative diseases, cardiovascular diseases, therapeutic options. Only articles published in the last 10 years are included, although older pivotal studies were added

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Phase 3: months 3 through 6 (optimization) You are now an experienced semaglutide user

Some patients report headaches , particularly in the early treatment phase

GLP-1 enhances insulin secretion